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Some of the signs and symptoms of this deficiency can include anemia, the buildup of too much acid in the body (metabolic acidosis), frequent infections and symptoms caused by problems in the brain (including seizures, intellectual disability and loss of coordination)

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Zinc accumulation induces ISR to initiate -cell fate in cells via the zinc-ATF4-ARX axis Gene set enrichment analysis (GSEA) of differentially expressed genes (DEGs) in SC- cells from the excessive-zinc group versus the control group revealed that pathways associated with -cell function, including regulation of gene expression in cells, regulation of -cell development, and regulation of insulin secretion, were significantly downregulated in the excessive-zinc group

However, further research is required to fully understand the interplay between GSH export from cancer cells and GSH levels in the TIF in vivo