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however, its dependence on invasive access and intermittent collection constrains its suitability for real-time and long-term monitoring

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Several intervention strategies were designed to affect HGF/c-Met signaling: inhibitors of HGF activation, HGF neutralizing antibodies Rilotumumab (AMG102), Ficlatuzumab (AV-299) and TAK701 [61], c-Met antagonists Onartuzumab, CE-355621, selective inhibitors of c-Met kinase activity Tivantinib, AMG-337, AMG-458, Foretinib, PHA-665725, MK-2461, PF-04217903 and SU11274, and nonselective multitarget inhibitors of RTK including c-Met such as Crizotinib and Cabozantinib

Collection of the eluted target in a neutral pH buffer and regeneration the column as soon as possible after the elution step can overcome this problem [8]