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In endurance sports, it is advisable to take a smaller dose (3-6 capsules per day) but prolonged over time (several months)

Thus, the use of ALA as an adjuvant in DM management is related to its capability to inhibit glycation which generates free radicals [82,86,87]

Contraindications & Precautions Absolute Contraindications Inborn errors of proline metabolism Hyperprolinemia type I & II Severe metabolic disorders preventing proper amino-acid utilization Hypersensitivity to amino-acid solutions (exceptionally rare) Relative Contraindications Severe hepatic impairment: Reduced amino-acid clearance risk of imbalance Renal failure: Risk of elevated BUN adjust total amino acids Sepsis or hemodynamic instability: PN may need staged introduction Fluid/electrolyte disturbances : Correct abnormalities before PN initiation Refeeding syndrome risk: Initiate PN slowly in malnourished patients Precautions Monitor for amino-acid imbalance or hyperaminoacidemia

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