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total GSH level decreased to one-fourth of the control in HCT116 cells while it decreased to two-fifth of the control treatment at SNU478 cell

The authors of this Review describe the current first-line treatment options for EGFR-mutant NSCLC, discuss mechanisms of acquired resistance to third-generation EGFR TKIs and new promising treatment strategies, such as bispecific antibodies, next-generation TKIs, antibodydrug conjugates, immunotherapy approaches and targeted protein degraders.

We recommend taking two tablets a day with a glass of water, one for lunch and dinner to optimize absorption and ensure full daily support