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10.1093/genetics/88.4.651 Genetics 70 LiuH.RudolfJ.JohnsonK

Important discoveries highlight the functions of important genes identified by gene ontology and pathway enrichment studies linked to p53 signaling, mitophagy, and protein degradation pathways, such as Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Zeng et al., 2025)

During pyroptosis, GSDMD-N inserts into the cell membrane, forming cytotoxic pores that compromise membrane integrity and facilitate the release of inflammatory mediators (32)

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