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Figure 61 Metabolism of phenytoin by phase 1 cytochrome P450 (CYP) and phase 2 uridine diphosphate-glucuronosyltransferase (UGT)
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Histone modification Histones modification, such as methylation, demethylation, acetylation and deacetylation, remodels the chromatin architecture which dictates histones either loosening or tightening their grip onto DNA to regulate MSC self-renewal, senescence and differentiation potential
