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Using systemic ketorolac can result in gastritis, ulceration with or without perforation, and/or bleeding, which can occur at any time, often without preceding symptoms

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Similarly, Cyp51a1 -/- knockout mice die around embryonic day 15, and the embryos exhibit several developmental malformations similar to ABS, such as skeletal malformations and heart defects

135,136 The underlying mechanism is that these cells lacking IDH2 show enhanced invasive behavior due to the increase in matrix metalloproteases, which depend on the NF-B pathway