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However, further research is needed to fully understand the role of MOTS-c in insulin regulation and its impact on metabolic homeostasis in humans

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While toll-like receptors (TLRs) signaling ensures protective immune response by recognizing invading pathogens and tissue-derived endogenous molecules, its overactivation perturbs the immune homeostasis by sustained release of pro-inflammatory mediators and subsequently underlies the development of many inflammatory diseases [296]