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[DOI] [PMC free article] [PubMed] [Google Scholar] Hayashi H

By targeting the PI3K/AKT and p53 pathways, metformin could also enhance NK cell cytotoxicity and may be used as an immunopotentiator for combination therapy with immunotherapy (Xia et al., 2020)

Antigen-presenting cells have the capability to mistakenly present their antigens to T cells, a process that triggers T cell-mediated autoimmune reactions and directly contributes to the development of RA (12, 13)

124 Nevertheless, if myostatin remains elevated, muscle regrowth is hampered, and if MnSOD activity is not sufficiently upregulated, unchecked oxidative stress can perpetuate tissue damage and maladaptive neurophysiological responses
