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Maybe aging

Hashemi M, Zandieh MA, Ziaolhagh S, Mojtabavi S, Sadi FH, Koohpar ZK, et al
There are 3 main isoforms: ApoE2, ApoE3, and ApoE4 in humans which represent 8, 77, and 15% allelic frequency, respectively (Huang and Mahley, 2014)
Chapped lips or dry, tight, dehydrated lips can happen to anyone because the lips do not contain oil glands like other areas of the skin