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Incidence of drug-induced hepatic injuries: a French population-based study
Figure 2 3.1 Receptor-mediated signaling pathways EEDs primarily compromise reproductive function by interfering with nuclear hormone receptor systems and membrane-associated signaling cascades that orchestrate normal reproductive physiology
In addition, ROS mediate cysteine sulfenylation of another ER stress sensor, inositol requiring enzyme 1 (IRE1), which activates nuclear factor-E2-related factor-2 (Nrf2) to generate an antioxidative response (Hourihan et al., 2016)
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