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Over time, high blood sugar levels can cause damage to the nervous system, while medications prescribed to maintain blood sugar levels can also lead to B12 deficiency

The basic circuits of reflex neural control elicited from the gut lumen consist of 1 ) intrinsic primary afferent (intrinsic sensory) neurons that project to the mucosa, where they are activated by an epithelial sensor, since enteric nerves do not project into the epithelium, but lie beneath it