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The blue vertical line corresponds to the active X chromosome, while the red line the inactive X chromosome

In the present study, we revealed that the renal tubulespecific knockout of Rest can alleviate IRI-induced AKI and attenuate AKI-to-CKD transition by inhibiting ferroptosis through transcriptional upregulation of glutamate-cysteine ligase modifier subunit (GCLM) via direct binding to its promoter region
It acts as a fuel source for immune cells, including white blood cells and some intestinal cells

Probiotic supplementation during tirzepatide therapy is not specifically studied but may support healthy microbiome adaptation
