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The existing methods for phenotypic selection of genetically modified mammalian cells are mainly based on three types of phenotypic markers: an exogenous drug resistance gene that permits screening for positive cells, a fluorescent protein, such as GFP, that allows isolating positive cells by FACS (fluorescence-activated cell sorting) (Chen et al., 1999), or a membrane protein that enables antibody-based immunomagnetic selection of positive cells (Plouffe et al., 2015)

Radiesse results typically last 12 to 18 months or longer, with gradual improvement continuing as collagen builds

Linnerbauer M, Wheeler MA, Quintana FJ (2020) Astrocyte crosstalk in CNS inflammation

( F ) Body weights of mice after AAV injection ( n = 911)