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Discussion Because of the large number of studies that analyzed blood oxidative stress markers in ASD children in recent years, here we were able to include 87 studies with 4928 ASD children and 4181 controls, and revealed that 18 oxidative stress-related markers were dysregulated in blood (serum or plasma) of children with ASD

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TJ consists of a variety of proteins, among which the transmembrane protein Occludin and the cytoplasmic protein Zonula occludens-1 (ZO-1) are key proteins for maintaining the structure of the TJ and the function of the intestinal epithelial barrier (Xu Q