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7c), the M pro seems more equilibrate in the presence of glutathione than the N3, in this case, the structure could be more stabilized with the glutathione due to its strong interaction, making of it possible irreversible inhibitor to the viral protein

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Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress

These responses trigger: (i) uncontrolled fluid secretion via epithelial Cl - /HCO 3 efflux