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The troches are formulated to ensure a slow and steady release of glutathione, maximizing the duration of its therapeutic effects
For example, the steric bulky substituent at ring A on 2c reduced the potency compared to the unsubstituted 2a , this is due to chelating ability towards the copper ions

In the context of OS treatment, AuNPs can be functionalized with various molecules, such as chemotherapeutics and targeting ligands, to deliver therapeutic payloads specifically to cancer cells while minimizing damage to healthy tissue [258]

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