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In fact, superoxide dismutase 2 (SOD2) in the mitochondrial matrix and SOD1 in the mitochondrial membrane gap convert O 2 to H 2 O 2 , which is converted to superoxide, the most common free radical

To improve consistency and therapeutic efficacy, steps should be taken towards standardizing cell sourcing protocols, preconditioning NSCs with MSC-derived secretomes to enhance survival and differentiation, and employing biomaterial scaffolds like electroactive polymer-based scaffolds that better replicate the electrical and structural cues of the pathological niche [111], thereby supporting NSC survival and guiding neural differentiation

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