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Further development of in vitro modeling should focus on generating precise replicas of the human brains complex structure by combining 3D cell cultures with organoids alongside microfluidic systems containing brain cells such as neurons and astrocytes and microglia to faithfully represent PD pathogenesis [81]

When not required to maintain their schedulei.e., weekends, holidays, etc.they sleep without difficulty, and will awaken spontaneously after a sleep period of normal length

Funding bodies and policymakers should prioritize investments in collaborative projects that bridge basic and applied research, ensuring a sustainable pipeline for mitochondrial disease innovations

As a result, this combination can be an effective option to extend survival for pleural mesothelioma patients who are not eligible for surgery