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This is why advanced delivery methods make such a difference

It features a 13-amino-acid N-terminal extension plus an arginine substitution at position 3, modifications that markedly prolong half-life and reduce binding to IGF-binding proteins in laboratory models
For instance, in rats portal vein concentrations reached 2.5 M and liver concentrations 147 M after oral gavage of 50 mg/kg phenformin 69

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