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Oncogene (2003) 22(47):736975.10.1038/sj.onc.1206940 2 TewKD

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Nonpharmacologic treatment options with published evidence of efficacy in patients with CIPN include chemotherapy dose reduction, discontinuation of the offending chemotherapeutic agent(s), acupuncture, avoiding cold temperatures/maintaining warmth, physical activity, and massaging affected areas ( TABLE 3 )

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5.4.4 Regulation of cell energy metabolism Mitochondria are the key organelles for cellular energy metabolism

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Then they wonder why the results feel underwhelming

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