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In experiments conducted on animals, it has been observed that the function of epidermal stem cells is impaired when telomeres undergo shortening ( Senescent cells can perturb their microenvironment by directly secreting senescence-related factors or by utilizing other means of communication, such as extracellular vesicles, leading to functional degradation ( Fibroblasts obtained from naturally aged skin elevate the synthesis of cysteine-rich protein 61 (CCN1), which impairs the balance of collagen and results in skin dysfunction

These microRNAs take part in the regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) that regulates the expression of numerous antioxidant proteins [113]

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