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Epigenetic factors such as the histone demethylase KDM6B, the transcription co-factor and chromatin remodeler Zmiz1, and the MSNP1AS long non-coding RNA (lncRNA) have been reported to modulate mTOR activity

[] Although PSA is a powerful tumor marker for PCa, it is controversial to use PSA levels for diagnosing PCa at an early stage since it may not differentiate between benign and malignant stages