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All putative ACO sequences were used to build a phylogenetic tree (see Supplementary Figure 1), which clearly shows a cluster of ancient ACOs within the clade of non-seed land plants and algae

Biesinger S, Michaels HA, Quadros AS, Qian Y, Rabovsky AB, Badger RS

[DOI] [PMC free article] [PubMed] [Google Scholar] Koornneef A., Leon-Reyes A., Ritsema T., Verhage A., Den Otter F.C., Van Loon L.C., Pieterse C.M.J

When cells are exposed to OS, gene mutations and other factors, the degradation of Nrf2 by the above complex may be impaired, such as: pro-oxidant conditions, autophagy disorders inhibit the combination of Keap1 and Nrf2 (Jain et al