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Peripheral markers of oxidative stress in Parkinson's disease

Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Germain A, Barupal DK, Levine SM, Hanson MR

1Active components in grapefruit juice include furanocou-marins such as 6, 7- dihydroxybergamottin (which is known to inactivate both intestinal and liver CYP3A4) as well as other unknown components that inhibit P-glycoprotein-mediated intestinal drug efflux and consequently further enhance the bioavailability of certain drugs such as cyclosporine