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Over the past decade, gemcitabine has remained the standard first-line therapy for advanced PDAC, primarily exerting its effects by inducing DNA damage, promoting ROS accumulation, and triggering ferroptosis [153]
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Autophagy is a phagocytic degradation process whose deregulation may contribute to neuronal cell death and is involved in the mechanisms of pathologic conditions, such as cerebral ischemia (Galluzzi et al., 2016
Cytochrome P450 enzymes (e.g
