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"We have identified a potential early target in the molecular ageing of the brain," the researchers say, "that may be important for the stability of cellular quality control." In the long term, these findings could help us better understand the development of neurodegenerative diseases such as Alzheimer's or Parkinson's, in which disturbances in protein degradation play a central role

Connectivity Map (CMap) Um banco de dados desenvolvido no Broad Institute (MIT/Harvard) que mapeia como milhares de compostos alteram a atividade gnica em todo o genoma humano

Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation

Cancer Res 55 , 13971400 (1995)