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By regulating the Nrf2/HO-1 pathway, A5 improves the activity of SOD and GPX and the level of glutathione, reduces the levels of iron deposition, 4-HNE and MDA, thereby improving the ferroptosis of neurons induced by TBI
Collectively, these data indicated that gut microbiota directly, or through the production of SCFAs, can impact the gut hormone levels, thereby influencing health and disease outcomes
