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The substantial comorbidity burdenapproximately 30% of inflammatory bowel disease patients develop anxiety or depressionhighlights the urgent need for dual-effect therapies that simultaneously address intestinal inflammation and gut-brain axis modulation

Moreover, existing animal models do not fully recapitulate the intricacies of the human microbiome and pathobiology

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Belenky, P., Christensen, K

While animal models have partially deciphered these mechanisms, human studies face substantial challenges: interindividual microbiota variability and confounding environmental exposures (e.g., antibiotic history) complicate causal inference