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At the same time, estrogen supplementation and BNDF upregulation promote the expression of other trophic factors such as the nerve growth factor (NGF) and the neuropeptide Y (NPY) (Barnea and Roberts, 2001
2.1.4 Impaired intestinal and renal excretion Approximately 90% of patients with gout exhibit impaired uric acid excretion, primarily due to reduced renal urate clearance (Nakayama et al., 2023
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