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Variability in cell isolation techniques (e.g., enzymatic SVF vs

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RNA-seq profiling confirmed that MEC-1/N M cells recapitulate the metabolic and proliferative transcriptional programs identified in unstimulated primary CLL/N M samples and demonstrated that these pathways are further reinforced upon 24-h -IgM stimulation in the MEC-1 model (Supplementary Fig

This is because the model is created by directly injecting MSU into the joint cavity, which does not mimic the natural induction of gout by UA saturation in the body, making it challenging to conclusively determine if PDA@Pt can treat acute gout by breaking down UA