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This was not the case during the implementation of the MDGs, where NorthSouth partnerships were most commonly developed from a Northern perspective, according to Northern priorities rather than attentive of Southern needs and views 39

Pricing Implications and Market Dynamics The cost-of-goods advantage of small-molecule manufacturing does not automatically translate into lower retail pricing, as pharmaceutical pricing is determined by factors including development costs, market competition, patent protection, payer negotiations, and value-based pricing frameworks

Upon oral administration, gastrointestinal epithelium acts as a physical and biochemical barrier for absorption of proteins resulting in low bioavailability (typically less than 12%)

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