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Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Jollow et al., 1973)
RCM can be idiopathic, familial, or secondary to systemic disorders, with familial cases often caused by sarcomeric gene mutations [57]
Among these, only about 14 carotenoids are found in human circulation
