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A newer human trial comparing standard, liposomal, and micellar (a related but different) delivery methods found that standard oral glutathione has historically struggled to meaningfully raise blood levels in some studies, including one comparison that found no significant change after 4 weeks at 500mg twice daily

FitzGerald GB, Bauman C, Hussoin MS, Wick MM

In a post-traumatic epilepsy rat model, an increase in PTGS2 protein and mRNA levels was noted after induction of seizures

(2) Attenuating Neuroinflammation: Building upon the evidence implicating cytokine signaling, microglial activation, and BBB disruption in depression pathophysiology, directly targeting neuroinflammation is crucial