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The hippocampus, and particularly the subgranular zone, has a high rate of cell proliferation (Jurkowski et al

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*Correspondence: Cosimo Giannini, [email protected] These authors have contributed equally to this work This article was submitted to Pediatric Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In particular, BHB, in addition to its role as an energy source, also has a variety of molecular signaling and regulatory functions in a wide range of human diseases ( 4.1 Epigenetic regulation BHB has been reported as a Class I histone deacetylase (HDAC) inhibitor and an endogenous neuroprotective epigenetic modifier ( 4.2 Gut microbiome Gut microbes are also known to be involved in the development of many diseases