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K.ZhengY.et al (2022)

Additionally, topiroxostat inhibits the ATP-binding cassette transporter G2 (ABCG2), which plays a key role in renal uric acid reabsorption and the secretion of uric acid from the intestines

10.3390/ijerph19031849 67

Cancer, such as liver cancer , can disrupt B12 metabolism, resulting in high levels
