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However, some people may have subtle symptoms of kidney disease that may include: changes in your urine, such as: making less urine needing to pee more often seeing blood in your urine foamy urine insomnia and fatigue trouble concentrating swelling in your arms, legs, or face, especially around your eyes muscle cramps What color is urine in stage 2 kidney disease

Certain groups may be more prone to B12-related issues: People are taking high-dose supplements especially without medical advice

Although it is known that abnormal lipid metabolism and adipose tissue accumulation possibly play important roles in linking obesity and T2D, the actual mechanisms are still unclear because not all obese people are insulin resistant or at high risk of diabetes [9]