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At the same intervals, the tails were observed for spasticity

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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

The role of VDD in osteonecrosis of the jaw (ONJ) is an increasingly discussed topic
