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Description
1998 double-blind crossover in psychogenic ED (PMID 9679884) No Phase 3 RCTs

& Geraghty, M

Atrogin-1 and MuRF1 expression in skeletal muscle is increased by cytokines or reactive oxygen species (ROS) and constitutive activation of NF-kB in animal models, leading to muscle loss and atrophy (Ringseis et al., 2013)

When hepatic lipid export is impaired, triglycerides accumulate in liver cells (hepatic steatosis), which disrupts insulin signaling and shifts metabolism toward fat storage rather than fat oxidation