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Through disruption of hydrophobic lipid-lipid and lipid-protein interactions, this change may result in structural changes to biomembranes and lipoproteins
[DOI] [PubMed] [Google Scholar] 354.Ferreira GK, Cardoso E, Vuolo FS, Michels M, Zanoni ET, Carvalho-Silva M, et al
The promiscuous disulfide bonds can occur within the mutant proinsulin or between a mutant proinsulin and a wild-type proinsulin, thus affecting the folding of wild-type proinsulin molecules as well
Increased expression of TLR2 can stimulate glial cells to secrete inflammatory factors, ultimately leading to TLR2-induced neuronal apoptosis [128, 129]
