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Increased GSTP1 expression has been reported in pre-neoplastic lesions in chemically induced animal cancer models (Satoh et al, 1985) and in many human tumours, relative to surrounding normal tissues (Shea et al, 1988)

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Taking into account the reaction geometry of thiol-disulfide exchange reactions, we raised the question which enzyme area interacts with which substrate 3,12 (Fig

This can enhance the early identification of patients at risk for complicated appendicitis, facilitate timely and appropriate interventions, and potentially reduce the incidence of adverse outcomes such as perforation and abscess formation