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1 Introduction Host cells initiate innate immune responses by recognizing conserved pathogen structures through pathogen-associated molecular patterns (PAMPs) and host damage-associated molecular patterns (DAMPs) through diverse pattern recognition receptors (PRRs), both of which can identify abnormal DNA ( In recent years, manganese has been widely concerned as an agonist of the cGAS-STING pathway

This process, known as Phase I and Phase II detoxification, creates a significant amount of "oxidative stress." Think of this stress like the exhaust coming from a car engine

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