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However, in contrast to the expectation, Atg5 -deficient mice did not develop liver injury after a toxic dose of APAP [151]

The mitochondria are constantly producing deupleted metabolic water from oxygen via oxidative phosphorylation, capturing the deupleted protons that pass through the ATPase pumps from the intermembrane space into the matrix (Seneff and Kyriakopoulos, 2025a)

The inhibition of DHODH only affects the changes of GPX4 in mitochondria
