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All human dosing is extrapolated from animal research

Additionally, celastrol down-regulated the expression of TNF- and iNOS and the immunoreactivity of CD40 and GFAP (a marker of microglia and astrocytes, respectively) [176]

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130 SIRT1 deacetylates NF-B, inhibiting pro-inflammatory cytokines (IL-6, TNF-) while promoting anti-inflammatory cytokines (IL-10), 35 limiting Th17 and Tc activation and supporting overall immune balance