glutathione s transferase polymorphisms and their biological consequences The Multifaceted Role of S-Transferases in Health Disease Overexpression of Glutathione S-Transferases in
Description
The result of methyl transfer is the conversion of SAM to S-adenosylhomocysteine (SAH or AdoHcy)
Excessive promotion of glutaminolysis (e.g., by cysteine deprivation) stimulates TCA cycle activity and therefore potently enhances mitochondrial respiration leading to mitochondrial hyperpolarization and increased production of ROS, which ultimately promotes lipid peroxidation and, hence, accelerates ferroptosis
[DOI] [PubMed] [Google Scholar] 101.Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, et al
The total number of cysteinyl residues codified in the human genome is about 550,000, found in about 72,000 proteins recovered from the UniProt database (www.uniprot.org)
