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Furthermore, the discovery that HLA-G-bearing exosomes (HLA-Gev) are potent mediators of systemic immune suppression has spurred interest in exosome-targeted therapies

doi: 10.1038/s41419-018-0753-0 123 DurandCPezetSEutamneHDemarquayCMathieuNMoussaLet al

We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says

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