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Description
Using the framework of iron as a catalyst for lipid peroxidation, along with evidence of lipid peroxidation and decreased glutathione (the substrate for the ferroptosis checkpoint inhibitor, glutathione peroxidase 4, GPX4), ferroptosis has been implicated as a pathological contributor promoting neuronal loss [31,32]
Published September 14, 2015
Despite its multifaceted therapeutic potential, the clinical performance of silymarin is hampered by poor oral bioavailability due to low aqueous solubility, hydrophobicity, enzymatic degradation, limited intestinal absorption, and rapid systemic clearance
The rSmGST protein was coated onto each well of 96-well plates (BIOFIL, Guangzhou, China) overnight at 4C
