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EA can increase the abundance of beneficial bacteria (such as Roseburia , Ruminococcus UCG-014 , Ruminococcus UCG-013 and Bacteroides ), and downregulate harmful bacteria such as escherichiacoli, e.coli and Klebsiella (Tan et al., 2023)

Bioactive functions for the -HETEs are not well understood, as no cognate receptor or second messenger has been identified to date 2,30

NRF2 is a potent transcription activator for genes mediating sulfur-involving redox reactions, and KEAP1 controls the NRF2 activity in response to the stimuli by utilizing reactivity of sulfur atoms

This mechanism has been proposed for the enhanced immune response observed after administration of vitamin C during cold infections [35]