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This however is not universally agreed upon

Physical health problems and diversity of medications used, including antidepressants, were difficult to control for

Crucially, resveratrol achieves these outcomes with a favorable safety profile, potentially circumventing the gastrointestinal intolerance associated with metformin, relapse risk after COCP discontinuation, and the teratogenicity concerns of anti-androgens

We use K m values in the ranges determined experimentally but there is much less information on V max values
