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Liebel F, Kaur S, Ruvolo E, et al
Clinical studies demonstrated that RIPC can prevent mitochondrial fusion, thereby preventing LL-IRI and improving muscle mitochondrial function
Once transported into neurons, MPP + inhibits the activity of mitochondrial complex I, leading to oxidative stress that directly causes the deformation and death of DA neurons, ultimately resulting in PD (Geng et al., 2019)
These results suggested that not all statins are equally effective in clinical settings, and further research into optimal dosing and specific statin classes is warranted
